Preventative Treatments

help prevent gonorrhea, chlamydia and syphilis


Antibiotics for STD prevention

DoxyPEP is a prescription antibiotic used to mitigate the risk of chlamydia, gonorrhea, and syphilis following unprotected sexual encounters, including oral sex.

In several studies, doxy-PEP reduced the risk of gonorrhea by about 55–60% and decreased the chances of developing chlamydia and syphilis by about 80% or more.

This revolutionary treatment works similar to emergency contraception, helping to proactively safeguard against STDs when taken promptly after unprotected sex. Take action and prioritize your sexual health with DoxyPEP – the optimal choice for protection and peace of mind.

Medication Details:

  • Available in 15, 30, & 40 doses
  • Take one dose orally as soon as possible after sex
  • Doxycycline Hyclate: 200mg


How does DoxyPEP Work?

DoxyPEP is an abbreviation for Doxycycline Post-Exposure Prophylaxis, which is a highly effective antibiotic used in the treatment of various bacterial infections, including sexually transmitted diseases (STDs) and sexually transmitted infections (STIs). The term “post-exposure” refers to the timeframe after a potential exposure to an STD, such as unprotected sexual activity. “Prophylaxis” indicates the preventive measures taken to avoid disease. If you have concerns about your risk of contracting STIs after engaging in sexual activity, taking DoxyPEP the day after can help prevent the establishment of certain STI bacteria in your body. Experience peace of mind and prioritize your sexual health with DoxyPEP.

Read more about DoxyPEP here.

FAQ &Information

But first, not all questions can be answered here.

DoxyPEP is new, and you undoubtedly have questions. One significant distinction between Shameless Care and other telemedicine companies is that we exclusively employ board-certified physicians. Rest assured that when you complete your medical intake form, you are free to ask your assigned provider any questions you may have. But our commitment to your well-being doesn’t stop there. Following your medication approval, you will have the opportunity to ask the doctor assigned to you an unlimited number of questions throughout the entire year.

How effective is DoxyPEP?

In clinical studies, DoxyPEP has shown promising results in reducing the risk of acquiring syphilis, gonorrhea, and chlamydia by approximately two-thirds when taken within 24 to 72 hours. It’s important to note that the current efficacy data is based on research conducted with gay and bisexual cisgender men as well as transgender women. Ongoing research is being conducted for cisgender women, as recommended by the CDC.

Will taking DoxyPEP lead to antibiotic resistance?

The risk of developing antibiotic resistance from a single dose of DoxyPEP is low. As the concern for antibiotic resistance in treating STDs continues to grow, this treatment option proves valuable in preventing the spread of these infections.

When is the ideal time to take DoxyPEP?

It is recommended to take your DoxyPEP tablet within 24 hours, but no later than 72 hours, after engaging in condomless sex. Condomless sex refers to oral, anal, or vaginal intercourse without continuous condom usage, involving skin-to-skin genital contact and/or fluid exchange.

Is an STD test necessary?

While an STD test is not required for receiving treatment, Shameless Care offers comprehensive STI testing, known for its thoroughness and accuracy. You can explore the available tests here.

Which STDs does DoxyPEP help prevent?

DoxyPEP has been found to offer preventive benefits against syphilis, gonorrhea, and chlamydia. It offers no protection whatsoever from viral infections such as HIV, HSV, Hepatitis, etc.

Does DoxyPEP have any side effects?

Common side effects of DoxyPEP are typically mild. If you experience stomach upset with antibiotics, taking them with food may alleviate the symptoms. It’s important to drink plenty of water when taking doxycycline to avoid esophagitis and to avoid lying down for 30 minutes afterwards. Some individuals may also experience increased sensitivity to the sun while taking doxycycline, so using sunscreen is recommended.

Is DoxyPEP FDA-approved?

Currently, DoxyPEP has not received official approval from the FDA and CDC, as they are reviewing available data and assessing its implications. However, the Department of Public Health in California (DPH) has recommended this treatment regimen for high-risk individuals, and many Infectious Disease Clinics have followed suit.

Is DoxyPEP safe for women?

Most of the research on the prevention of sexually transmitted infections (STIs) has focused on men who have sex with men, as this population faces the highest risk of STIs. However, we understand that many women are concerned about the impact of antibiotics on vaginal health.

Our medical team expects the occasional use of 200 mg of doxycycline, as per this protocol, would not negatively impact vaginal flora.

Hear from ourCustomers

5.0 out of 5 stars (based on 171 reviews)

Very easy to use

May 22, 2024

The entire process is incredibly easy to do. The medication arrived quickly.

Experienced no problems – highly recommend this product.


Response from Shameless Care

Thank you very much! Our doctors and pharmacy partners are QUICK! If you ever have an issues with Shameless Care, we will give you 100% of your money back. Just ask.

Very fast, very easy to use!

May 21, 2024

Each step is highlighted, guiding you through the process.


Response from Shameless Care

thank you! -Robert @ Shameless Care

No embarrassment or judgmental looks.

May 19, 2024

The privacy alone is more than enough to encourage others to utilize Shameless Care! The service provides ease, convenience, along with great customer support. I expected to be buried in questions and neverending emails, but to my very happy surprise, it is the complete opposite. I highly and happily recommend anyone take advantage of this truly amazing opportunity for help with whatever you need.


Response from Shameless Care

Thank you so much! Don’t forget that you get $40 off your next test.

Easy as 1,2,3

May 15, 2024

I was able to fill out my application

Answer questions from your online dr about current meds as well as any issues that may or may not be a complication with the prep prescription .

Submit payment and within a week or so you will have your prescription.


Easy to use!

May 14, 2024

Very easy to use. No weird looks from lab techs.

Thank you for giving me the option to do this anonymously.


Response from Shameless Care

Thank you!

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